Roche Licenses Sefaxersen from Ionis Pharmaceuticals
Roche has entered into a licensing agreement with Ionis Pharmaceuticals to acquire the rights to sefaxersen for the treatment of complement-mediated diseases.
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Filed: 2026-10-23 AccNo: 0001140361-26-040631 Size: 186 KB Item 7.01: Regulation FD Disclosure Item 8.01: Other Events Item 9.01: Financial Statements and Exhibits
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Roche has entered into a licensing agreement with Ionis Pharmaceuticals to acquire the rights to sefaxersen for the treatment of complement-mediated diseases.
Roche announced positive interim phase III data from the IMAgINATION study showing that investigational sefaxersen achieved a statistically significant 43.1% reduction in proteinuria relative to placebo at 37 weeks in adults with primary IgA nephropathy. The antisense oligonucleotide inhibitor of complement factor B was well tolerated with no new safety signals and is designed as a once-monthly subcutaneous injection for self-administration.
BB Biotech reported that it fully divested its remaining position in Ionis Pharmaceuticals during the third quarter of 2026.