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Ionis Pharmaceuticals shares are trading higher after the company and Otsuka said the Phase 3 FUSION study of ulefnersen met its primary endpoint.

BenzingaBenzinga Newsdesk

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    Ionis Pharmaceuticals announced positive phase III results for two partnered programs: ulefnersen (FUSION study) for FUS-ALS met its primary endpoint with Otsuka planning regulatory discussions, and sefaxersen (IMAgINATION study) for IgAN showed statistically significant proteinuria reductions with Roche continuing the trial. These wins come after recent clinical setbacks in cardiovascular programs but follow FDA approval of Zanvastro for Alexander disease.

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    8-K filing — IONIS PHARMACEUTICALS INC (IONS)

    Filed: 2026-09-23 AccNo: 0001140361-26-037371 Size: 187 KB Item 7.01: Regulation FD Disclosure Item 8.01: Other Events Item 9.01: Financial Statements and Exhibits